Inosine

 

Item No. Chemical Name CAS No. Structure Typical Usage CN Name
1 Inosine 58-63-9 58-63-9 Inosine Pranobex 肌苷
2 1,3-Dihydroxyacetone 96-26-4 1,3-dihydroxyacetone (2,4-diaminopteridin-6-yl)methanol Hydrochloride 1,3-二羟基丙酮

 

Atorvastatin Calcium Intermediates

 

Item No. Chemical Name CAS No. Structure Typical Usage CN Name
1  Methyl isobutyrylacetate;
Methyl 4-methyl-3-oxopentanoate (M1)		 42558-54-3 Methyl isobutyrylacetate; Methyl 4-methyl-3-oxopentanoate Atorvastatin Calcium
阿托伐他汀钙		 异丁酰乙酸甲酯（M1）
2 (4R,CIS)-1,1-DIMETHYLETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE;
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate (AST-8)		 125971-94-0 (4R,CIS)-1,1-DIMETHYLETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE Atorvastatin Calcium
阿托伐他汀钙		 阿伐他汀钙侧链ATS-8
3 4-Fluoro-Alpha-(2-Methyl-1-Oxopropyl)-Gamma-Oxo-N,Beta-Diphenylbenzene Butaneamide;
2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide (M4)		 125971-96-2 4-Fluoro-Alpha-(2-Methyl-1-Oxopropyl)-Gamma-Oxo-N,Beta-Diphenylbenzene Butaneamide (M4); 4-fluoro- α -[2-methyl-1-oxopropyl]- γ -oxo-N, β - diphenylbenzene butaneamide Atorvastatin Calcium
阿托伐他汀钙		 阿托伐他汀钙(M4)
4 (4R-CIS)-1,1-DIMETHYLETHYL-6-(2-(2-(4-FLUOROPHENYL)-5-(1-ISOPROPYL)-3-PHENYL-4-((PHENYLAMINO)CARBONYL)-1H-PYRROL-1-YL); tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate (L1) 125971-95-1 tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate; (4R-CIS)-1,1-DIMETHYLETHYL-6-(2-(2-(4-FLUOROPHENYL)-5-(1-ISOPROPYL)-3-PHENYL-4-((PHENYLAMINO)CARBONYL)-1H-PYRROL-1-YL) Atorvastatin Calcium
阿托伐他汀钙		 阿托伐他汀钙 L1

Etodolac Intermediates

Item No. Chemical Name CAS No. Structure Typical Usage CN Name
1 Methyl 3-oxovalerate (3-OXO) 30414-53-0 Methyl 3-oxovalerate, Etodolac Intermediate M1 Etodolac依托度酸 3-氧代戊酸甲酯(依托度酸 3-OXO)
2  7-ETHYL TRYPTOPHOL (E2) 41340-36-7 7-ETHYL TRYPTOPHOL Etodolac依托度酸 7-乙基色醇 (依托度酸 E2)
2 Methyl 2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetate 122188-02-7 methyl 2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetate; Etodolac-methyl-ester Etodolac依托度酸 依托度酸甲酯

Jan 2022

 

Item No. Chemical Name CAS No. Structure Typical Usage CN Name
1 p-Nitrophenyl 2-(furfurylsulfinyl)acetate 123855-55-0 p-Nitrophenyl 2-(furfurylsulfinyl)acetate Lafutidine 拉呋替丁
2 2-Fluoropyridine-5-boronic acid pinacol ester 444120-95-0 2-Fluoropyridine-5-boronic acid pinacol ester Selpercatinib Selpercatinib塞尔珀卡替尼(LOXO-292, LOXO-292)中间体
3
2,6-Difluoro-3,5-dimethoxyaniline
 651734-54-2 2,6-Difluoro-3,5-dimethoxyaniline Pemigatinib 培米加替尼(INCB054828)中间体
4 2-Amino-5-chloro-2′-fluorobenzophenone 784-38-3 2-Amino-5-chloro-2'-fluorobenzophenone Fluphenazine 氟奋乃静 中间体
5 Methyl 2-oxoindoline-6-carboxylate 14192-26-8 Methyl 2-oxoindoline-6-carboxylate Nintedanib
6 6-(Chloromethyl)uracil;
6-(chloromethyl)pyrimidine-2,4(1h,3h)-dione		 18592-13-7 6-(Chloromethyl)uracil Tipiracil
7 Chloromethyl isopropyl carbonate 35180-01-9 Chloromethyl isopropyl carbonate Tenofovir
8 (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate
Diethyl (tosyloxy)methylphosphonate		 31618-90-3 (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate Diethyl (tosyloxy)methylphosphonate Tenofovir
9 ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate 874638-80-9 ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate Sofosbuvir
10  Ethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate 211915-84-3 Ethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate Dabigatran 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-YL]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester
11 7-Methoxy-1-tetralone; 7-methoxy-3,4-dihydro-2H-naphthalen-1-one 6836-19-7 7-methoxy-3,4-dihydro-2H-naphthalen-1-one Dezocine; Agomelatine

Feature Intermediates for API manufacturing from China

 

Item No. Chemical Name CAS No. Structure Typical Usage CN Name
1 (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8 (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid sitagliptin phosphate monohydrate
2 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride sitagliptin phosphate monohydrate
3 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine 145783-14-8 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine Ticagrelor
4 (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol 155899-66-4 (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol Ticagrelor
5  (1R,2S)-2-(3,4-difluorophenyl) cyclopropanamine 1156491-10-9 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Ticagrelor
6 Tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine Carboxylate 198904-85-7 Tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine Carboxylate Atazanavir 1-Boc-2-[4-(2-pyridinyl)benzylidene]hydrazine
7 (2R,3S)-3-(tert-Butoxycarbonyl)amino-1,2-epoxy-4-phenylbutane 98760-08-8 (2R,3S)-3-(tert-Butoxycarbonyl)amino-1,2-epoxy-4-phenylbutane Atazanavir (2R,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane
8 2,4-difluorobenzyl amine 72235-52-0 2,4-Difluorobenzylamine Dolutegravir
9 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine; (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol 132335-44-5 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Duloxetine HCl
10 1-Fluoronaphthalene 321-38-0 1-Fluoronaphthalene Duloxetine HCl
11 (2R,3S,4S,5S)-2,3,4-Tris(benzyloxy)-5-((benzyloxy)methyl)-5-hydroxycyclohexanone 115250-38-9 (2R,3S,4S,5S)-2,3,4-Tris(benzyloxy)-5-((benzyloxy)methyl)-5-hydroxycyclohexanone Voglibose
12 cis-Tert-butyl 5-oxohexahydrocyclopenta[C]pyrrole-2(1H)-carboxylate 146231-54-1 cis-Tert-butyl 5-oxohexahydrocyclopenta[C]pyrrole-2(1H)-carboxylate

Nitrogen heterocycles

Item No. Chemical Name CAS No. Structure Typical Usage CN Name
1 oxazolo[4,5-b]pyridin-2(3H)-one; 60832-72-6 oxazolo[4,5-b]pyridin-2(3H)-one Crizotinib,  azamethiphos 恶唑吡啶酮
2  2-Amino-3-hydroxypyridine；
2-Aminopyridin-3-ol		 16867-03-1 2-Amino-3-hydroxypyridine Crizotinib,  azamethiphos 2-氨基-3-羟基吡啶
3 3-methyl-5-chloromethylpyridine hydrochloride；
3-(Chloromethyl)-5-methylpyridine hydrochloride		 1007089-84-0 3-(Chloromethyl)-5-methylpyridine hydrochloride Rupatadine 3-甲基５-氯甲基叱咤盐酸盐
4 3-Amino-6-Methoxypyridazine;
6-Methoxypyridazin-3-amine		 7252-84-8; 3-Amino-6-methoxypyridazine 瑞卢戈利
Relugolix		 3-氨基-6-甲氧基哒嗪 1589503-98-9 as HCl
5 3,6-Dichloropyridazine 141-30-0 3,6-Dichloropyridazine Sulfachloropyridazine
6 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine 145783-14-8 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine 替卡格雷中间体 Ticagrelor
7 4-Chloro-6-Ethyl-5-Fluoropyrimidine 137234-74-3 4-Chloro-6-ethyl-5-fluoropyrimidine 伏立康唑中间体
Voriconazole
8 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carbonitrile;
6-fluoro-3-hydroxypyrazine-2-carbonitrile		 356783-31-8 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carbonitrile 法匹拉韦中间体
Favipiravir
9 6-Bromo-3-hydroxypyrazine-2-carboxamide 259793-88-9 6-Bromo-3-hydroxypyrazine-2-carboxamide 法匹拉韦中间体
Favipiravir
10 3-Aminopyrazine-2-Carboxylic Acid 5424-01-1 3-Aminopyrazine-2-carboxylic acid Favipiravir 3-
氨基吡嗪-2-羧酸
11 5-Methylpyrazine-2-carboxylic Acid 5521-55-1 5-Methylpyrazine-2-carboxylic Acid Glipizide | Aximosi
12 2-Amino-4-hydroxypyridine hydrochloride 1187932-09-7 2-Amino-4-hydroxypyridine hydrochloride
13 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine 150728-13-5 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Bosentan
14 2-Amino-4,6-dimethoxypyrimidine 36315-01-2 2-Amino-4,6-dimethoxypyrimidine
15 4,6-Dihydroxypyrimidine 1193-24-4 4,6-Dihydroxypyrimidine
16 2,3-Difluoro-5-chloropyridine; 5-Chloro-2,3-difluoropyridine 89402-43-7

Product Baed on Fermentation and Enzymatic Synthesis

 

Item No. Chemical Name CAS No. Structure Typical End-Use Remarks
1 3,4-DIHYDROXYBENZOIC ACID 99-50-3 Erlotinib;
Etamivan;
Itopride;
protocatechuic acid
2 HYDROXYTYROSOL;
3,4-Dihydroxyphenylethanol		 10597-60-1 Hydroxytyrosol ( Known as major substance in Olive Extract)
3 3,4-Dihydroxycinnamic acid; Caffeic Acid 331-39-5 Caffeic Acid, antioxidiant for skin care product
4 Shikimic Acid; 138-59-0 Oseltamivir （Tamiflu）
5 L-tert-Leucine 20859-02-3 L-tert-Leucine
6 L(+)-2-Aminobutyric acid; LABA 1492-24-6
7 L-Norvaline; (S)-2-Aminopentanoic Acid; 6600-40-4 Norvaline
8 L-Tyrosine ;(S)-Tyrosine 60-18-4 L-tyrosine
9 Niacinamide (Vitamin B3, Vitamin PP) 98-92-0 Nicotinamide
10 (S)-1-Boc-3-hydroxypiperidine;
(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate;(S)-N-Boc-3-hydroxypiperidine		 143900-44-1 (S)-1-Boc-3-hydroxypiperidine Ibrutinib
11 (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-Tetrahydro-9-[[Tris(1-Methylethyl)Silyl]Oxy]-5H-Cyclohepta[B]Pyridin-5-One 1190363-46-2 (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one Solifenacin
12 (S)-1-(4-Phenyl-1H-Imidazol-2-Yl)Ethanamine 864825-23-0 (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine Eluxadoline
13 (R)-(+)-1-(1-Naphthyl)ethylamine 3886-70-2 (R)-(+)-1-(1-Naphthyl)ethylamine Cinacalcet HCl